时红波 综述，段钟平 审校

【中文摘要】：肝再生增强因子（ALR）除了促进肝再生，保护肝损伤之外，可能在肝脏的器官形成和发育中也发挥着重要作用。介绍了ALR在肝脏中的生物学功能和机制研究的最新进展，并归纳总结了ALR在肝脏疾病的诊断和治疗中的应用。指出ALR可能通过线粒体途径调控肝细胞的凋亡，从而参与肝脏的修复和再生。未来ALR可能作为肝衰竭患者肝再生及预后评估的候选分子，并有望成为临床治疗严重肝病和肝衰竭的有效药物。

【英文摘要】：Recent studies have found that augmenter of liver regeneration (ALR) not only promotes liver regeneration and protects the liver from damage, but may also play an important role in the formation and development of the liver. The recent progress in research on the biological function and action mechanism of ALR in the liver is reviewed, and the application of ALR in the diagnosis and treatment of liver diseases is summarized. It is suggested that ALR may regulate hepatocyte apoptosis through the mitochondrial pathway to promote liver repair and regeneration. In the future, ALR may be used as a candidate for evaluating liver regeneration and prognosis in patients with liver failure. ALR holds promise as an effective medicine for treating severe liver disease and liver failure.

【中文关键字】：肝再生增强因子；肝再生；肝疾病

【英文关键字】：augmenter of liver regeneration; liver regeneration; liver diseases